Paradoxical Ca 2+ Rises induced by Low External Ca 2+ in Rat Hippocampal Neurones
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Puerarin facilitates Ca(2+)-induced Ca(2+) release triggered by KCl-depolarization in primary cultured rat hippocampal neurons.
The effects of puerarin on behaviour and brain neuronal activity in animal studies have been described previously. However, molecule mechanisms underlying these effects were poorly understood. Here, we examined the regulation of puerarin on the Ca(2+) signals in primary rat hippocampal neurons using Fura-2 based calcium imaging techniques. Application of puerarin had no effect on the basal intr...
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4 Raffaella Tonini, Teresa Ferraro, Marisol Sampedro-Castañeda, Anna Cavaccini, Martin 5 Stocker, Christopher D. Richards and Paola Pedarzani* 6 7 Research Department of Neuroscience, Physiology and Pharmacology, University College London, 8 London, UK. 9 Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Genova, Italy. 10 11 *To whom correspondence should be ad...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2003
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jphysiol.2003.041871